Upon his father's death in 1833, he succeeded as second Baronet of Hanby Hall and as heir apparent to his grandmother, with the courtesy title of Lord Huntingtower.
Dysart sat as Member of Parliament for Ilchester, alongside his younger brother the Hon.
In 1841 he succeeded his grandmother in the earldom of Dysart and to her estate at Ham House in Surrey.
Lord Dysart married Maria Elizabeth, daughter of Sweeny Toone, in 1819.
Lord Dysart died on 23 September 1878, aged 83, and was succeeded in the earldom by his grandson, William John Manners Tollemache, 9th Earl of Dysart, his son William, styled 'Lord Huntingtower', having predeceased him.