He is best known for his 2005 debut studio album Autumn Flow, which featured singles such as "Daniel", the title track and his signature song "This Old Love".

[2][3] They made their first Australian home in Lane Cove, and Lior studied at Killara High School and the University of New South Wales.

He sent it to a number of record labels but failed to secure a deal, and released the album independently, late in 2004.

In February 2006, Lior released a live album, Doorways of My Mind, recorded at the Northcote Social Club.

The album consisted mostly of tracks from Autumn Flow as well as some new material such as "Diego and the Village Girl", "Burying Chances" and "Avinu Malkeinu" (a traditional prayer).

[10] In 2008, Lior toured extensively, both in his home country of Australia and abroad including feature performances at the Edinburgh Festival.

[11] In 2009, Lior was approached by children's television show Giggle and Hoot series producer Clare Gerber, and was asked to write a song.

The song played nightly on ABC 2 just before 7:00pm, and marked the end of children's programming on the channel for the day.

[21] In 2016, Lior worked with producer Tony Buchen to write an orchestral score for The Wider Earth, a Queensland theatre production based on Charles Darwin's journey on HMS Beagle.

[25] In 2016 Lior co-wrote and recorded a children's album with The Idea of North and Elena Kats-Chernin for the HUSH Foundation.

Created for the dual purpose of raising funds for the children's hospital as well as making original music to be played in the wards, the album A Piece of Quiet featured original music written to lyrics written by the children in the hospital wards and was released in October 2016.

In 2019, Lior formed the musical group Air Land Sea with Nadav Kahn and Tony Buchen.

In a 2015 interview, Lior mentioned working for the charities Cambodian Children's Trust and Global Poverty Project as well as supporting Oscar's Law.