Ann quit porn in 1997 due to an AIDS scare in the industry, but resumed performing in February 2006.

[8] In December 2014, she launched Porn Stars Boot Camp, a consulting firm, and also announced her retirement from performing in adult films.

Prior to beginning her adult entertainment career, Ann appeared as a "Snapple Girl" on The Howard Stern Show.

[12] Ann appeared alongside Rayveness and Cory Chase in Season 4, Episode 7 of the Showtime series Billions titled Infinite Game.

[2] During the first two years of her adult film career, she was under contract with Metro/Cal Vista and shot only once a month with porn artist John O'Rourke.

[18][non-primary source needed] She decided to resume performing in February 2006 after being asked to do a boy/girl photo shoot for Suze Randall.

[6][7] Hustler contacted her to offer her the part on the day of the vice-presidential debate, which she viewed to learn Palin's mannerisms in preparation for the role.

[30] Ann made her directorial debut with the film, Hung XXX,[31] released on September 22, 2009, by Justin Slayer International.

[39] In December 2009, it was announced that Ann had signed on to be the spokeswoman for RealTouch, a mechanized artificial vagina produced by AEBN.

Better Halves with Lisa Ann and Bret Raybould is a comical therapy session that journeys into the world of dating, sex, and relationships.

[9] Ann appeared on The Howard Stern Show as a "Snapple Girl" prior to the launching her adult entertainment career.

[46] Ann was ranked fifth on Complex magazine's list of "The Top 100 Hottest Porn Stars (Right Now)" in 2011.

[12] Ann appeared alongside Rayveness and Cory Chase in Season 4, Episode 7 of the Showtime series Billions, titled "Infinite Game".

[55] In March 2010, Ann appeared in a public service announcement for the Free Speech Coalition on the topic of copyright infringement of adult content, directed by Michael Whiteacre.

[56][57] On October 14, 2010, Ann announced that she would only be shooting scenes with condoms after a male performer in the industry was diagnosed with HIV.

[58] In August 2012, she called for legislation mandating condom use in heterosexual adult films and questioned the standards of syphilis treatment for performers by industry doctors.

[62] Ann has campaigned to destigmatize interracial pornography by speaking out about the treatment of black performers in the industry and the lack of work for them.

[55] She stated that if she had not worked in the adult film industry, she would have liked to become a sports agent or writer, blogger, and reporter.

[68][69] A source close to Kardashian spoke to Us Weekly and confirmed that they met at a gym, but denied Ann's claim that they were dating.

[72] In October 2014, speculation was raised whether Ann and 18-year-old Notre Dame football player Justin Brent were dating when the two appeared at a game together.

[74][75] In November 2014, she commented via her Twitter account regarding requests made to her by former New York Rangers hockey player Michael Del Zotto.

[76] In a February 2014 interview with GQ magazine, sportswriter Myles Brown, Ann wrote, "...if dudes could be with Victoria's Secret models, that's how I look at athletes.

The contest, "Win a Date with Lisa Ann", was co-sponsored by the studio and offered an all-expense-paid trip to the national championship game for the best trick shot video submitted.