Beginning her career in the early 1990s, Arrindell is most known for her role as Vanessa Breaux-Henderson in Madea's Family Reunion (2006), Heather Comstock in the series In the House (1995), and Toynelle Davis in Livin' Large (1991).

She co-starred in several made-for-television movies, including A Lesson Before Dying (1999) alongside Don Cheadle and Cicely Tyson, and Disappearing Acts (2000) starring Sanaa Lathan.

Arrindell appeared opposite Isaiah Washington in the thriller The Sin Seer (2015), The Immortal Life of Henrietta Lacks (2017), starring Oprah Winfrey.

Arrindell recently starred in the film 12 Angry Men And...Women on Apple TV with Wendell Pierce and BET's Favorite Son (2021).

Arrindell has guest starred on several other network series, including Random Acts of Flyness, Bull, Elementary, Madam Secretary, Law & Order SVU, and Notorious.