Henson was born in Westchester County, New York and attended Byrum Hill High School.

[2] Henson has an undergraduate degree from Harvard University where she studied ancient Greek and folklore mythology.

[6] In 1993 Henson was named president of worldwide production at Columbia Pictures.

[7] Prior to this her work was on production of movies such as Lethal Weapon and the Batman films.

[8][9] In 2012 she joined other companies who sought to avoid connections with Chick-fil-A due to their opposition to gay marriage.