She played domestic cricket for New South Wales, as well as Warwickshire and Wiltshire.
[1][2] Following her playing career, she became a coach, leading Australia, Perth Scorchers and England, among others.
[3] Keightley played nine Tests and 85 One Day Internationals for the Australia women's national cricket team between 1995 and 2005[1] and represented New South Wales in the Women's National Cricket League from 1996/97 to 2004/05.
[4] She holds the record for the highest ever maiden ton in Women's ODI history (156*)[5] She played 91 matches in the domestic national cricket league, scoring 3081 runs at 37.12 with 3 centuries, 21 fifties and a highest score of 144*.
On 30 October 2019, Keightley was appointed head coach of the English women's team, the first woman to hold the post full-time.