Lopes was a member of the R&B girl group TLC, alongside Tionne "T-Boz" Watkins and Rozonda "Chilli" Thomas.

Besides rapping and singing on TLC recordings, Lopes was the creative force behind the group, receiving more co-writing credits than the other members.

She also designed some of their outfits and the stage for their FanMail Tour and contributed to the group's image, album titles, artworks, and music videos.

On April 25, 2002, Lopes was killed in a car accident in Roma, Jutiapa, Honduras, while volunteering at a children's development center.

The group was renamed TLC, derived from the first initials of its members at the time: Tionne Watkins, Lisa Lopes and Crystal Jones.

[14][15] Things did not work out with Jones, and TLC's manager Perri "Pebbles" Reid brought in Damian Dame backup dancer Rozonda Thomas as a third member of the group.

After another fight between the couple, in the early morning hours of June 9, 1994, Lopes tossed numerous pairs of Rison's newly purchased sneakers into a bathtub and lit them on fire.

Rison then had the damaged marble tub replaced with a cheaper fiberglass model, which went up in flames immediately when she set the shoes on fire.

Later in 1995, Lopes recorded a well-received verse to the rap version of "Freedom" of the soundtrack from the Black Panther-based docudrama Panther with fellow female hip-hop artists such as Queen Latifah, MC Lyte, Patra, Yo-Yo, Salt 'n' Pepa and Meshell Ndegeocello.

In 1997, Lopes was featured on the remix to Lil' Kim's "Not Tonight", alongside Missy Elliott, Angie Martinez and Da Brat.

[18] During and after the release of FanMail, Lopes made it known to the press on multiple occasions that she felt that she was unable to express herself in TLC fully.

In response, Lopes sent a reply through Entertainment Weekly issuing a "challenge" to Watkins and Thomas to release solo albums and let the fans decide the winner of TLC.

[21]Watkins and Thomas were unconvinced by the strategy behind 'The Challenge' and declined to take up the offer, though Lopes remained firm in her support for the idea.

[22] Things were heated between the band for some time, with Thomas speaking out against Lopes, calling her antics "selfish", "evil", and "heartless".

"[24] In 1998, Lopes hosted the short-lived MTV series The Cut, in which a list of aspiring pop stars, rappers, and rock bands competed against each other in front of judges.

The show's winner, which ended up being a male-female rap duo named Silky, was promised a record deal and funding to produce a music video, which would then enter MTV's heavy rotation.

A then-unknown Anastacia finished in third place, but ended up securing a record deal after Lopes and the show's three judges were impressed by her performance.

In July 2001, Lopes appeared on the singers' edition of Who Wants to Be a Millionaire along with Joey McIntyre, Tyrese, Nick Lachey, and Lee Ann Womack.

[citation needed] In 2008, Lopes' family opened UNI Studios, which she had created for the purpose of recording solo projects, to the public.

Among the album's 13 tracks was also a posthumous duet with Tupac Shakur that was assembled from the large cache of unreleased recordings done prior to his murder in 1996.

The Japanese import includes a bonus track called "Friends", which would later be sampled for "Give It to Me While It's Hot" on TLC's fourth album 3D.

In 2008, Lopes' family decided to work with producers at Surefire Music Group to create a posthumous album in her honor, Eye Legacy.

In 2012, on the eve of the tenth anniversary of her death, "Fantasies", an unreleased track by Bootleg featuring Lopes, was uploaded to SoundCloud.

[52] In September 2000, Lopes was reported missing after failing to attend a family gathering and a major press conference in Las Vegas.

The boy, Bayron Isaul Fuentes Lopez, was following behind his brothers and sisters when he stepped off the median strip and was struck by a van driven by Stephanie, Lopes' personal assistant.

[55] In the documentary The Last Days of Left Eye, Lopes is shown choosing a casket for the child from a local funeral home.

The vehicle rolled several times after hitting two trees, throwing Lopes and three others out of the windows, and finally coming to rest in a ditch at the side of the road.

She died instantly of "fracture of the base of the cranium" and "open cerebral trauma", and was the only person fatally injured in the crash.

[59] Engraved upon her casket were the lyrics to her portion of "Waterfalls", stating "Dreams are hopeless aspirations, in hopes of coming true, believe in yourself, the rest is up to me and you.

Most of the footage was shot with a handheld camera, often in the form of diary entries filmed by Lopes while on a 30-day spiritual retreat in Honduras with sister Reigndrop, brother Ronald and members of the R&B group Egypt.