Born and raised in Albany Creek, Queensland, Lisa and her identical twin sister, Jessica Origliasso, performed in show business at a young age.

[5][6][7][8] In late 2011, Origliasso started a group called the Dead Cool Dropouts with Tyler Bryant, mostly done using GarageBand on a Macintosh computer.

[2] At age sixteen, Lisa and Jessica ventured into acting, being cast in a small role in the children's television series Cybergirl,[16] as villains Emerald and Sapphire Buxton, respectively.

[2][16] Lisa and Jessica impressed music executive Hayden Bell with their demo tracks and were signed to Excalibur Productions Australia as songwriters in 2004.

[23] The following year, they released their debut album, The Secret Life of... (2005), which spawned their first major hit, "4ever", peaking at number two on the ARIA Singles Chart and being certified platinum, denoting 70,000 copies shipped in Australia.

"[34] Lisa spent her time listening to blues music and eventually travelled to Nashville to write,[33] teaming up with American singer Tyler Bryant to form the Dead Cool Dropouts.

[40] Months after this performance, in 2012, the Veronicas finally revealed that they would release a new song called "Lolita" for their new album, which was known as Life on Mars at the time.

[42][43] Life on Mars was to be released by the end of 2012; however, Warner Music pushed the date back to early 2013, and eventually the record was shelved altogether.

[44][45] Because of this, Lisa and Jessica hired a lawyer in a bid to get out of their contractual obligations with the label and were successful, so by 2013 the Veronicas became an independent act.

[66] In 2006, Lisa and Jessica Origliasso joined Steve Irwin's Wildlife Warriors Worldwide, a charity that deals with the protection of animals and their natural environments.

[68] In 2010, the twins were honoured as Wildlife Warriors of the year for their efforts in publicising animal protection and conservation on a worldwide scale.