Simon Bond (David Sturzaker) debuts in May, while Zara Carmichael (Elisabeth Dermot Walsh) begins appearing in June.
A month later, Rob Hollins (Chris Walker) was introduced as the husband of Karen, followed by their children, Imogen (Charlie Clemmow) and Jack (Nicholas Woodman).
Lisa was introduced as the mother of Izzie Torres (Jasmin and Nicole Parkinson) and the partner of Daniel Granger (Michael Chambers).
Having previously abandoned Izzie at the reception of the Mill Health Centre, Lisa turns up on Daniel's doorstep and informs him that she has had a change of heart.
Karen was created by series producer Peter Eryl Lloyd as a replacement for former receptionist Vivien March (Anita Carey).
Karen is the wife of Letherbridge police sergeant Rob (Chris Walker) and the mother of Imogen (Charlie Clemmow) and Jack (Nicolas Woodman).
Her storylines in the programme have included becoming a healthcare assistant, having an abortion, the breakdown and reconciliation of her marriage, becoming a foster parent and having amnesia after being involved a car accident.
[5] When Cherry arrives at the Mill Health Centre, she turns heads amongst the male staff, specifically Jimmi Clay (Adrian Lewis Morgan) and Daniel Granger (Matthew Chambers).
However, she tries to form a relationship with Simon Bond (David Sturzaker), unaware that he is gay until Zara Carmichael (Elisabeth Dermot Walsh) informs her.
Cherry sees Michelle Corrigan (Donnaleigh Bailey) drinking vodka in the surgery, but after talking to Simon, decides to not tell anyone.
Simon is subjected to homophobic abuse from colleague Charlie Bradfield (Phillip McGough) once he discovers his sexuality and learns of his affair with Will.
[7] Zara was introduced as a general practitioner at the Mill Health Centre and she remained a regular character until April 2012, when Walsh temporarily left to go on maternity leave.
Rob is the husband of Karen (Jan Pearson), a receptionist at the Mill Health Centre, as well as the father of Imogen (Charlie Clemmow) and Jack (Nicolas Woodman).
Rob's storyline in the programme have included disagreeing with Karen on aborting their baby, accidentally causing his wife's amnesia, suffering from post-traumatic stress disorder, becoming a foster parent, being accused of police brutality and the breakdown and reconciliation of his marriage.
Rob's PTSD was explored over the duration of a year with the climax coinciding with Mental Health Awareness Week in 2018, with the storyline being revisited in 2021.
His storylines in the series have included his secret relationship with Zara Carmichael (Elisabeth Dermot Walsh) and completing a degree at university.
Following the completion of his degree, it was confirmed by producer Peter Eryl Lloyd that the character would face numerous life decisions that ultimately resulted in his exit.