Lisch nodule, also known as iris hamartoma, is a pigmented hamartomatous nodular aggregate of dendritic melanocytes affecting the iris,[1] named after Austrian ophthalmologist Karl Lisch (1907–1999), who first recognized them in 1937.

[2] The first published use of the term Lisch nodule was in the New England Journal of Medicine "Medical Progress" series article of December 31, 1981 (Riccardi VM: Von Recklinghausen Neurofibromatosis.

These nodules are found in neurofibromatosis type 1, and are present in greater than 94% of patients over the age of six.

[1] They are clear, yellow-brown,[3] oval to round, dome-shaped papules that project from the surface of the iris.

[3] Immunohistochemistry stains positive against the proteins vimentin and S-100, and points to an ectodermal origin for the nodules.