It was founded in memory of Mar Augustine Kandathil, shortly after his demise, according to his original vision and plans, in 1957, by Cardinal Joseph Parecattil as a token of his devotion to St. Thérèse de Lisieux.

The hospital has departments including Anaesthesia, Cardiac Anaesthesiology, Cardio Thoracic Surgery, Cardiology, Pulmonary Medicine, Critical Care Medicine, Dentistry, Dermatology, Diabetology, Emergency Medicine, ENT, Gastroenterology, Nephrology, Neurology, Neurosurgery, Obstetrics & Gynaecology, Orthopaedics, Urology, Radiology, Medical Social Work, Oncology, Pain & Palliative, Pathology, Gastrointestinal Surgery and Ophthalmology.

Department of Cardiac Anaesthesiology is one of the largest Cardio thoracic practices in South India.

Educational institutions within the hospital include: The Lisie Heart Institute is a tertiary care Interventional Cardiology and Cardiac Surgery Unit at the Mar Augustine Memorial Lisie Hospital.

The Heart Institute is one of the leading centres for Interventional cardiology and Cardiac surgery in the state of Kerala.