Lisle-sur-Tarn (French pronunciation: [lil syʁ taʁn]; Occitan: L'Illa d'Albigés) is a commune in the Tarn department in southern France.

Lisle-sur-Tarn sits along the A68 motorway, halfway between Toulouse and Albi, within the Gaillac wine region and next to the Tarn river.

This extensive heritage, in a region that is still producing wine nowadays, plays an important role in the local tourism-oriented economy.

Lisle-sur-Tarn station has rail connections to Toulouse, Aurillac, Albi and Rodez.

The town's grid-like layout includes straight, uniform streets lined with half-timbered, red-brick houses.