Lissodrillia simpsoni, common name Simpson's drillia, is a species of sea snail, a marine gastropod mollusk in the family Drilliidae.

(Original description) The polished, shining shell contains (including the protoconch) 6½ whorls.

The remainder is transversely ribbed with 8–10 smooth, rounded, nearly straight, stout ribs, extending from suture to suture, which begin with the end of the protoconch part, and fail at the last third of the body whorl, which is marked only by a silky fine incremental stride.

The aperture and the siphonal canal are very short and wide, and the notch is deep and large, rounded, leaving no fasciole.

[3] This species occurs in the Gulf of Mexico, the Caribbean Sea and the Lesser Antilles; in the Atlantic Ocean off Northern Brazil at depths between 9 m and 82 m. This species has been found as a fossil in Quaternary strata of the United States (Florida, North Carolina) and also in Pliocene strata in North Carolina; age range: 2.588 to 0.781 Ma.