Based on inscriptions and coins of the 3rd century BCE, we know the city allied with King Magas of Cyrene, and joined the League of Oreians.
[3] The order in which Flaminius Cornelius mentions it with the other bishoprics in the west part of the island agrees very well with its actual location in Agios Kirikos area, near the small village of Sougia, 70 km south of Chania.
[4][5] Of all the towns which existed on this part of the coast, Lissus alone seems to have struck coins, a fact which agrees very well with the evidence supplied by its situation, of its having been a place of some trading importance.
The harbour is mentioned in the Periplus of Pseudo-Scylax, and the types of the coins are either maritime, or indicative of the worship of Dictynna, as might have been expected on this part of the island.
Near the church of the Panaghia are what appear to be vestiges of an ancient temple, consisting of granite columns, and white marble fragments, architraves, and pediments.
An ancient theatre, or Odeon, was uncovered at the site of Lissos in 2023, one of the great archaeological discoveries of that year.
Beside the Asclepieum and the Roman necropolis there are also two Greek Orthodox churches: Agios Kyrikos has some nice frescoes, and the chapel of Panagia is built with ancient marble blocks.