Lissy was born as the only child to Nellikaattil Pappachan (Varkey)[1] and Aleyamma at Pazhanganad, Pukkattupadi, Kochi in Kerala.

Lissy is most remembered for her roles in Chithram, Thalavattom, Odaruthammava Alariyam, Mutharamkunnu P.O.

As she stated in an interview with manam magazine[5] she was introduced to Tamil films by Kamal Haasan as his heroine in his home production, Vikram.

She fell in love with the noted film director Priyadarshan, and married him on 13 December 1990.

[6] After marriage, Lissy gave up acting and adopted the name Lakshmi for religious reasons.