This is a list of player transfers involving Top 14 teams before or during the 2021–22 season.
The list is of deals that are confirmed and are either from or to a rugby union team in the Top 14 during the 2020–21 season.
It is not unknown for confirmed deals to be cancelled at a later date.
Perpignan were promoted to the Top 14 following the 2020–21 Rugby Pro D2 season whilst Agen were relegated to Rugby Pro D2 following the 2020–21 season.
Biarritz were then also promoted after defeating Bayonne in the promotion-relegation match, with Bayonne relegated to the Rugby Pro D2 for the 2021–22 season.