List of Billboard Hot 100 number-one singles from 1958 to 1969

During 1958–1969 the chart was based collectively on each single's weekly physical sales figures and airplay on American radio stations.

Note: The year-end number-one singles for 1963, 1965 and 1966 were "Surfin' U.S.A." by The Beach Boys, "Wooly Bully" by Sam the Sham & the Pharaohs, and "California Dreamin'" by The Mamas and the Papas, respectively, which peaked at numbers 3, 2, and 4, also respectively, and thus are not included here.

A number of artists had number-one singles on their own as well as part of a collaboration.

The following artists were featured in top of the chart for the highest total number of weeks during 1958–1969.

The following songs were featured in top of the chart for the highest total number of weeks during 1958–1969.

The Beatles earned the most number-one hits (18 songs) and remained the longest at the top of the Billboard Hot 100 chart (55 weeks) during 1958–1969.
Elvis Presley remained at the top of the Billboard number-one singles chart for 22 weeks during 1958–1969.
The Supremes scored 12 number-one singles during 1958–1969, spending 22 weeks atop the Billboard Hot 100 chart.
" The Twist " by Chubby Checker topped the chart in two different chart years and ranked as the most successful song in the chart's history, until surpassed by The Weeknd 's " Blinding Lights " (2020).