[1][2] Seth Gecko (George Clooney) is the main protagonist and brief antagonist in the 1996 film, From Dusk till Dawn and its 2001 spin-off video game of the same name.
Compared to his violent brother, Seth is a more calm, rational individual, always intending to keep his word to release his hostages if they comply with his demands.
In the spin-off video game, Seth has been condemned to death for the Titty Twister murders and is now in the Rising Sun high-security prison, a converted tanker floating off the coast of New Orleans.
Richie Gecko (Quentin Tarantino) is a deranged rapist and murderer who, along with his brother Seth, kidnaps a preacher and his two kids and flees for the safety of a remote nightclub in Mexico.
Santanico Pandemonium (formerly known as Esmeralda) (portrayed by Salma Hayek in the first film and Ara Celi in the third) is the 102 year old vampire queen and main attraction as an exotic and seductive dancer at the Titty Twister.
She begins the vampires' feeding frenzy when she kills Richie Gecko in a spur-of-the-moment surge of bloodlust, triggered by his bleeding hand.
Santanico, in human form, sits on the lap of a dazed and wounded biker (portrayed by Gregory Nicotero of KNB Effects).
Her personality as Esmeralda was a nice, young woman who was caring and gentle, but as Santanico, she's very cruel, seductive and inconsiderate, even planning to turn Seth into her slave.
When the remaining survivors fight back against the vampires, Sex Machine is killed by Seth and transforms into a large, rat-like creature.
Sex Machine tries to kill Seth, but is shot in the chest by Kate with a crossbow and tossed into a fire pit, setting him ablaze.
Pete is non-fatally shot by Richie, but grabs a gun and engages in a shootout with the Geckos that ends with him being set on fire and burnt alive.
Buck is forced to join arch rival Sheriff Lawson in an action-packed, kill-or-be-killed battle to stop these vampires and save their own lives.
He escapes to Mexico with blueprints for a million-dollar heist, but on his way to the rendezvous point, he gets into an accident and stumbles upon the Titty Twister bar, where he gets a bite by the vampire.
Edgar McGraw (James Parks) appears briefly in two scenes in From Dusk Till Dawn 2: Texas Blood Money.
His fellow Texas Ranger Otis Lawson references his cold demeanor and distracted nature, including the murder of his father Earl.
Along with Madrid's gang, Johnny and Esmeralda embark on an adventure filled with colorful and unsavory characters who lead them straight into the fight of their lives.
After Esmerelda leaves town with Johnny Madrid, The Hangman tracks them to the vampire's bar where he becomes caught up in the epic battle for survival.
He is bitten and turns into a vampire but manages to remain a fragment of his humanity and impales Quixtla allowing Madrid and Bierce to escape.
While the vampires continue to feast on the saloon's patrons, Bierce joins forces with Johnny Madrid, Esmerelda, her father the Hangman and several other characters: together they try to escape through the establishment's extensive subterranean stone dungeons.
After the final credits have rolled, Bierce appears last time in a short scene: he's in a bar in the present day, drinking with a random guy and is recounting own story.
The guy doesn't believe him, but Bierce says he can prove it, and proceeds to tear the skeptic's heart out and eat it, revealing that he was a dark power of some kind all along (in this context, probably a vampire).
She frequently appears in Richie's libidinous visions as a beautiful woman urging him to set her free and commit violent crimes, until they finally meet at the Titty Twister.
Carlos Madrigal (Wilmer Valderrama) is the criminal Seth and Richie are going to meet to negotiate their entry to El Rey, who is also the leader of the vampires.
Although the character Sex Machine exists in the film as a patron of the Titty Twister, his "real identity" as a professor was created for the series.