A homicide detective in Portland, Oregon, he starts seeing disturbing and inexplicable things; ordinary faces seem to become animal-like or monstrous.
Returning home from work (in the pilot episode) he finds his Aunt Marie making dinner with his girlfriend Juliette.
Hank has no hint that Grimms or Wesen exist, until, by way of his association with Nick, that world is slowly revealed to him.
Sergeant Drew Wu (played by Reggie Lee) is the go-to technical expert who provides backgrounds, hard drive contents, and general cyber knowledge to the detectives.
She comes to Portland to close her brother's "Spice & Tea Shop", but, as an apothecary herself, winds up running it, after becoming smitten with Monroe.
The non-human traits and abilities appear when Wesen are aggressive or otherwise emotionally agitated, which is referred to as wogeing from the German wogen, meaning surge.
Separately, the seven Royal Houses in Europe are aware of the Wesen community in the series and are vying to restore their former influence in the world.