The star of almost every episode of this rotating series was either Gene Barry as Glenn Howard, Anthony Franciosa (credited as Tony Franciosa) as Jeff Dillon, or Robert Stack as Dan Farrell.
The pilot for this series was the 1966 TV-movie Fame Is the Name of the Game starring Franciosa, along with Susan Saint James (making her debut) and guest stars Jill St. John, Jack Klugman and Robert Duvall.
The first-season episode "Pineapple Rose" starred actor Cliff Potts rather than one of the usual leads; produced by the Tony Franciosa segment team it was allocated to Gene Barry segment due to his cameo appearances.
In the third season, Robert Culp (two episodes), Peter Falk and Robert Wagner substituted as "special guest leads" for four episodes in Franciosa's place.
The episode "A Capitol Affair" featured guest lead Suzanne Pleshette with Gene Barry providing cameos.