Guest Stars: Jack Warden (Jubal Tatum) Garth has a visitor from Colombia, Enrique Cuellar, who has inherited a critical piece of property in the middle of Shiloh used to move cattle.
In Casper they have several adventures revolving around a wrestling match involving an old acquaintance of the judge who is fighting for the championship, and Steve's romantic interest in one of the saloon girls who reminds him of a past lost love.
Guest Stars: Aldo Ray (Frank Krause), Michael Shaughnessy (Peter Muldoon) Trampas and Steve decide to join up with Teddy Roosevelt's Rough Riders.
Guest Stars: Charles Bickford (Tucker McCallum) An old cowhand and a "greenhorn" join the Shiloh hands for a cattle drive to Moose Jaw, Canada.
The actress was unhappy with the lack of development of her character,[1] while at the same time Executive Producers Frank Price and Roy Huggins disliked the idea of the Virginian having a regular romantic interest.
Guest Stars: Tammy Grimes (Angela Clark), Ed Nelson (Ralph Slocum) Garth recalls his early days as a judge in Medicine Bow in one particularly dangerous murder case.
Guest Stars: Clu Gulager (Jake Carewe), Patricia Barry (Alice Finley) A bear brings to the surface the lack of respect a father has for his son.
Guest Stars: Fabian (Martin Beldon) Garth trails a woman to San Francisco whom he believes is part of a con game involving a railroad deal.
Guest Stars: Dana Wynter (Leona Kelland), Robert Vaughn (Simon) The Virginian, Trampas, and Steve help a vegetarian with a chimp who is framed for murder and a single woman with a group of orphans.
Guest Stars: David Wayne (Martin Reese), John Banner (Gus Schultz) A wealthy woman persuades The Virginian to take her to the badlands to a gang led by the previous foreman of Shiloh.
Guest Stars: Bradford Dillman (Sam Harder), John Dehner (Bleeck), Edward Asner (George Johnson) An outlaw gang traps Garth and Betsy and several stagecoach passengers at a way station.
Guest Stars: Joan Blondell (Rosanna Dobie), John Dehner (Frank Sturgis) In Santa Rita The Virginian meets an old flame, Savannah, who has been seeing a very jealous local man, Gordie Madden.
Guest Stars: Robert Redford (Matthew Cordell) Judge Garth is asked by an old friend, Wade Anders, to take his eldest son Hank to work as a hand at Shiloh.
Guest Stars: Albert Salmi (Brother Thaddeus / Willie Caine) After delivering a herd of cattle to New Orleans, The Virginian meets and falls for a mysterious woman, Marie Valonne.
Guest Stars: Madlyn Rhue (Marie Valonne) Steve Hill befriends a disheveled deaf-mute named Judd and convinces The Virginian to gives him a job at Shiloh ranch.
Guest Stars: Robert Lansing (George Calhoun) Garth recognizes opera singer Elena as a close friend from his early days as a lawyer.
Guest Stars: Yvonne De Carlo (Helen Haldeman / Elena) After winning $1,000 at poker, Trampas returns to Logan, New Mexico to repay several debts and see the girl he'd left, but she's married to the Marshal.
Guest Stars: Pat O'Brien (J. Jimerson Jones), John Banner (August the Head Waiter) A failed British rancher returns to Medicine Bow a wealthy man but conflicted by his cowardice in the Army.
Guest Stars: Peter Graves (Robert Gaynor), Richard Jaeckel (Pat Wade) An injured Trampas is thought to be a stagecoach robber according to a Sheriff and is reported dead to Shiloh.
Guest Stars: Miyoshi Umeki (Kim Ho), Richard Carlson (Sheriff Marden), Frank Overton (Mr. Umber) Betsy's Chicago visitor has a shaky visit, starting with Garth ignoring his wire.
Guest Stars: Darren McGavin (Mark Troxel), Hugh Marlowe (Billings) The Virginian tracks the man who killed a young friend in a bank robbery.
Guest Stars: Diana Millay (Alma Lowell), Peter Breck (Jess Carver) A storm forces Randy to stay with Betsy and three of her friends at a mansion where they spent time in their youth.
Guest Stars: Ruta Lee (Judith Holly), Joseph Campanella (Corbett) Trampas wins the job of bringing an injured neighbor's bride to him from Laramie.
Guest Stars: Katherine Crawford (Anna Swenson) A horse thief's daughter staying at Shiloh is drafted to help an injured Randy, who can't walk due to a spinal injury, with therapy.
Guest Stars: Brenda Scott (Billie Jo Conrad) News that Betsy and Randy found over $900 in gold in a cave on Shiloh brings two men to the ranch looking for money.
Guest Stars: Jeremy Slate (Johnny Kane / Benton), Dick Foran (Mr. Duggan) Note: This is the last episode to feature Gary Clarke as a regular cast member.
The Virginian arrives in Monolith, Arizona to buy cattle from the Landers family but finds himself in the middle of a feud between them and the city marshal Merle Frome and his brother Ben.
Sue Ann leads a dull life as the daughter of a homesteader taking care of her father, two young brothers, and their hired hand Joe who would like to marry her.
A wounded man and woman wanting horses tell Clay the stage with a vaccine was robbed and they are chasing the outlaw gang so The Virginian and David join them.
The Virginian helps the widow of a local businessman prove her innocence when first her husband is killed in a fire followed by his right hand man who names her as he dies.