The United States Ambassador to Moldova is the official representative of the President and Government to the head of state of Moldova.

As with all Poland Ambassadors, the ambassador to Moldova is nominated by the President of Poland and confirmed by the Parliamentary Commission of the Foreign Affairs.

The ambassador serves at the pleasure of the president, and enjoys full diplomatic immunity.

Following the dissolution of the Soviet Union, the Supreme Soviet of the Moldavian SSR declared itself independent on August 27, 1991, and renamed itself the Republic of Moldova.

The Republic of Poland recognised Moldova and established diplomatic relations July 14, 1992.