The United States recognized the government of Buenos Aires, the predecessor to Argentina, on January 27, 1823.

Caesar Augustus Rodney was appointed as American Minister Plenipotentiary to Buenos Aires.

[1] Diplomatic relations between the U.S. and Argentina were interrupted but not severed in June 1944 when the U.S. government recalled its ambassador in a dispute with the newly appointed dictator Edelmiro Julián Farrell.

Normal relations were resumed with the appointment of a new ambassador in April 1945 when Argentina declared war against Germany.

Ambassador in Buenos Aires is the Bosch Palace, listed on the State Department's Register of Culturally Significant Property.