The following is a list of envoys, ministers, and ambassadors that the United States has sent to Bolivia.

As a point of note, the first Ambassador of the United States to Bolivia was John Appleton, who served as the charge d'Affaires from January 3, 1849, to May 4, 1849.

Since September 15, 2008, there has been no official Ambassador with the office being held by a chargé d'Affaires.