The United States government recognized Tajikistan on the same day.

Diplomatic relations were established on February 19, 1992 in an announcement by President Bush.

A temporary embassy was opened by Chargé d'Affaires ad interim Edmund McWilliams on March 13, 1992 in the Avesto Hotel, pending the appointment of an ambassador.

[1] The first ranking ambassador was Stanley Tuemler Escudero, who presented his credentials on October 19, 1992.

[2] On October 25, 1992, six days after Ambassador Escudero's arrival, Embassy Dushanbe was closed and all U.S. personnel were withdrawn because of the civil war in Tajikistan.