Series regulars Zach Braff, Donald Faison, Sarah Chalke, John C. McGinley, Judy Reyes and Christa Miller all earned nominations for their acting.

Braff's performance was very praised, and he was nominated for an Emmy and three Golden Globe Awards.

[1] The show won the 2002, 2008, and 2009 Humanitas Prize in the 30-minute category for the episodes "My Old Lady", "My Long Goodbye" and "My Last Words" respectively.

[2] While the episodes "My Screw Up", "My Way Home" and "My Fallen Idol" received nominations.

The fifth season episode "My Way Home" earned the show a Peabody Award, the industry’s most competitive honor.