The chancellor of the University of Illinois Chicago is the principal administrative officer of the university and a member of the faculty of each of its colleges, schools, institutes and divisions.

The chancellor is appointed by the Board of Trustees following nomination by the president of the University of Illinois System.

The chancellor performs those duties that are assigned by the president and that are consistent with the actions of the Board of Trustees.

[1] In September 1982, the University of Illinois System consolidated its two Chicago campuses, the University of Illinois at Chicago Circle and the University of Illinois at the Medical Center, to form the University of Illinois at Chicago.

The current chancellor is Dr. Marie Lynn Miranda, who has been serving since July 2023.