The list of shipwrecks in May 1943 includes ships sunk, foundered, grounded, or otherwise lost during May 1943.
For the loss of the Italian cargo ship Paolo on this date, see the entry for 28 February 1943.
( Red Cross): World War II: The hospital ship (3,222 GRT, 1924) was torpedoed and sunk in the Pacific Ocean off Queensland (27°16′59″S 153°59′13″E / 27.28306°S 153.98694°E / -27.28306; 153.98694), probably by I-177 ( Imperial Japanese Navy), with the loss of 332 of the 396 people aboard.
World War II: The Design 1019 cargo ship (5,589 GRT, 1919) was torpedoed and sunk in the Atlantic Ocean (47°51′N 25°53′W / 47.850°N 25.883°W / 47.850; -25.883) by U-607 ( Kriegsmarine).
World War II: The Type IXC submarine was depth charged and sunk in the Atlantic Ocean (10°00′N 35°35′W / 10.000°N 35.583°W / 10.000; -35.583) by USS Jouett and USS Moffett (both United States Navy) with the loss of seven of her 54 crew.