It continues the path of a local road that begins at a junction with LA 401 just north of Attakapas Landing on Lake Verret.

It provides access to the Woodland Bridge across the Gulf Intracoastal Waterway for Belle Chasse and an area of New Orleans known as the Algiers Lower Coast.

The roadway curves to the northeast, traversing a corner of Orleans Parish, and passes a small cluster of industrial facilities located alongside the Gulf Intracoastal Waterway.

The highway then passes the entrance to the upscale English Turn residential community and country club.

The route connects General de Gaulle Drive, a major thoroughfare through the Algiers area of the city, with LA 406 via the Woodland Bridge across the Gulf Intracoastal Waterway.

The divided four-lane highway loops to the north and proceeds across the high-level Woodland Bridge over the Gulf Intracoastal Waterway, located along the Orleans–Plaquemines parish line.

Returning to grade, LA 407 intersects General de Gaulle Drive, which continues ahead through Algiers toward the Crescent City Connection bridge spanning the Mississippi River in Downtown New Orleans.

The route continues in this capacity through the residential Old Aurora neighborhood until reaching an intersection with LA 428 (General Meyer Avenue).

The route connects northern Baton Rouge with Greenwell Springs, a rural community within the Central city limits.

Several blocks later, the highway passes through an interchange with I-110 at exit 6, connecting to Downtown Baton Rouge and Natchez, Mississippi.

Jutting out from this junction is Veterans Memorial Boulevard, a local road that provides access to Baton Rouge Metropolitan Airport.

It continues northeast in this capacity until reaching a junction with LA 37/LA 64 (Greenwell Springs Road), which parallels the Amite River.

LA 411 continues along the bayou until reaching a junction with US 190 (Airline Highway) in Livonia, connecting with the cities of Baton Rouge and Opelousas.

The highway then skirts the Pointe Coupee Parish line for a short time before crossing it at a junction with LA 3091 (Flynn Road).

Shortly afterward, the route turns west at an intersection with LA 414 (Island Road) and makes a long loop alongside False River through Jarreau and Dupont to Ventress.

The route continues northeast to a junction with LA 415 in Hermitage at the west bank levee of the Mississippi River.

It then turns northward alongside the west bank levee of the Mississippi River past Williamsport and the Angola Ferry landing.

The highway travels through the northern central portion of the parish, just south of the Mississippi state line.

The route is located entirely within East Baton Rouge Parish and is known locally as Old Hammond Highway.

Shortly before exiting the city limits, LA 426 narrows to two lanes at an intersection with Boulevard de Province.

The route proceeds eastward and intersects LA 3245 (O'Neal Lane) before terminating at US 190 (Florida Boulevard) just west of the Amite River.

Both designations were removed from the route in 1942 when an extension of Florida Boulevard from Downtown Baton Rouge to the Amite River was completed.

[4][16][44][45] As of 2018, the portion of LA 427 in East Baton Rouge Parish is under agreement to be removed from the state highway system and transferred to local control.

Just before the local name changes to Behrman Place, the center lane is replaced by a median, and the route proceeds to an intersection with General de Gaulle Drive.

LA 428 turns west onto General de Gaulle Drive, a divided six-lane thoroughfare with a wide right-of-way that includes a drainage canal.

Approaching this junction, the westbound carriageway widens to five lanes to accommodate traffic exiting onto the Crescent City Connection into Downtown New Orleans.

[12][13][47][49] Passing through the interchange, the roadway narrows to a divided four-lane highway, and LA 428 soon crosses back into Jefferson Parish and enters the city of Gretna, where the local name changes to Burmaster Street.

and engages into a roundabout with Mardi Gras Boulevard, a local road, at grade level between the two bridge spans.

Shortly afterward, LA 428 turns to the northeast, and state maintenance ends at the five-point intersection of Lamarque, Vallette, Verret, and Hermosa Streets.

[13][47][48][49] As of 2019, a small portion in Jefferson Parish intersecting LA 23 is under agreement to be removed from the state highway system and transferred to local control.