It then curves southeast through the Kisatchie National Forest and proceeds into the village of Georgetown.

Here, the highway crosses the four-lane US 165 and zigzags north and east through the center of town.

Heading southeast from Georgetown, LA 500 crosses the Little River in LaSalle Parish.

[4] The route heads due east from US 165 then turns northward after crossing the Union Pacific Railroad (UPRR) tracks.

Louisiana Highway 510 (LA 510) runs 9.46 miles (15.22 km) in De Soto Parish.

Louisiana Highway 514 (LA 514) runs 12.19 miles (19.62 km) from East Point to Womack.

Louisiana Highway 517 (LA 517) runs 6.03 miles (9.70 km) from Mount Lebanon to Bryceland.

[27] The route heads in a general northeast direction from an intersection with US 79 at the northern tip of Homer.

[32] The route heads west from LA 1 at Lucas, a point within the southeast corner of Shreveport.

Louisiana Highway 525 (LA 525) runs 10.05 miles (16.17 km) from Spring Ridge to Shreveport.

LA 526 then travels through a large industrial park on the city's western edge, passing near Union Pacific's Reisor Yard.

[37] Louisiana Highway 528 (LA 528) runs 11.20 miles (18.02 km) from Bossier Parish to Dixie Inn.

Louisiana Highway 530 (LA 530) runs 10.23 miles (16.46 km) from Oil City to Belcher.

Louisiana Highway 534 (LA 534) runs 20.40 miles (32.83 km) from the Kisatchie National Forest to Haynesville.

LA 3049 continues the route south on Grimmett Drive and makes a right to the north on Dixie Shreveport Road.

Shortly, after, LA 538 curves to the north-northwest, crossing under the Kansas City Southern Railway tracks.

Shortly after, LA 538 curves to the northeast and then to the north as it crosses a bridge over Caddo Lake.

After 1.3 mi (2.0 km), LA 538 enters the town of Oil City, gaining the local name of Kerley Avenue.

After crossing underneath the Huey P. Long Bridge on US 90, LA 541 follows a sharp bend in the river known as Nine Mile Point.

The route ends shortly afterward at LA 18 (4th Street) adjacent to a bascule bridge spanning the canal on that highway.

Louisiana Highway 544 (LA 544) runs 15.39 miles (24.77 km) from Lincoln Parish to Ruston.

Near the end of its route, LA 546 crosses the Kansas City Southern Railway (KCSRW) tracks via an overpass and travels through an interchange with I-20 in Cheniere.

It ends a short distance later at an intersection with US 80 and southbound LA 15, connecting to West Monroe.

Louisiana Highway 547 runs 3.06 miles in an east–west direction from a local road to its Western terminus at LA-845 in Clarks.

As part of Louisiana DOTD's "right-sizing" program, the entire route is set to be deleted and transferred to local control.Louisiana Highway 548 (LA 548) runs 7.79 miles (12.54 km) in Chatham.

LA 549 then passes the Union Wildlife Management Area and curves to the northeast at Truxno.