(LSA disputed) Many man-made chemicals with little human history have been recognized to catalyze intense spiritual experiences, and many synthetic entheogens are simply slight modifications of their naturally occurring counterparts.
While synthetic DMT and mescaline are reported to have identical entheogenic qualities as extracted or plant-based sources, the experience may wildly vary due to the lack of numerous psychoactive alkaloids that constitute the material.
[44] In the Vodou faith of Haiti, alcoholic drinks such as rum are consumed to be able to allow spirits called "lwa" to enter one's body and help them find the motivation for or strength to survive everyday struggles or life.
This ritual involves the consumption of alcohol in a controlled manner, symbolizing the transformation of negative emotions and attachments into wisdom and compassion.
[92][93] The Maya ritually administered alcohol enemas as an entheogen, sometimes adding other psychoactive substances, seeking to reach a state of ecstasy.
[105] The Tarahumara people gather every year during Easter week (semana santa) and drink large amounts of Tesgüino together while following rituals.
The end of the ritual culminates in the consummation of the eucharist, consisting of a goblet of wine and a Cake of Light, after which the congregant proclaims "There is no part of me that is not of the gods!
"[111] Holy water is important to the Ethiopian Orthodox Tewahedo Church and regarded as healing from demonic possession and for treating sick people, particularly in cases of mental illness.