Holmes Chapel is a civil parish in Cheshire East, England.
It contains eleven buildings that are recorded in the National Heritage List for England as designated listed buildings.
The parish is occupied by the large village of Holmes Chapel and the surrounding countryside.
What is now the Crewe–Manchester railway line passes through the parish, and there are two listed structures associated with this, the Twemlow Viaduct and a nearby boundary post.
Also running through the parish is the River Dane, and a bridge crossing it is listed.