Listrac-Médoc (French pronunciation: [listʁak medɔk]; Occitan: Listrac de Medòc) is a commune in the Gironde department in the Nouvelle-Aquitaine region in southwestern France.

The commune is situated in the Médoc on the Route nationale 215, between Bordeaux and Le Verdon-sur-Mer.

Lying 15 kilometres (9 mi) northwest of the city of Bordeaux, the village is best known as one of the six appellations of the great wine-growing regions of the Médoc.

In a region where a mere 20 metres (70 ft) can be the difference between a great wine and an average one, its distance from the beneficial effect of the Garonne means that its wines are not as highly rated as those of the other appellations.

Nonetheless, it is home to many vineyards whose blends of cabernet sauvignon, merlot and cabernet franc can age over a long period.