In rehearsals, the sketches were tweaked, re-ordered and re-written in order to accommodate the rapid costume and make-up changes required by the principal performers.

Anthony Head (as the Prime Minister) and Ruth Jones (as barmaid Myfanwy) reprised their roles for certain performances, also appearing as backup dancers during Daffyd's song.

[4] A special version of the stage show featuring several celebrity guests was performed at the Hammersmith Apollo in London on 22 November 2006, and was shown by the BBC on 16 March 2007 as part of Comic Relief.

Celebrity performers included Kate Moss as Vicky Pollard's sister Katie, Dawn French as lesbian barmaid Myfanwy, and the real Dennis Waterman who appeared to sing the Minder "feem toon" with his pint-sized counterpart.

The show also featured cameo appearances from Russell Brand, Patsy Kensit, Kate Thornton and DJ Chris Moyles.

[5] Several sketches are adjusted to reflect local content, such as the locality referred to as a 'shithole' by travel agent Carol Beer (Preston in Blackpool, Bolton in Manchester,[6] Wolverhampton or Chelmsley Wood in Birmingham, Derby in Nottingham, Strabane in Belfast, Shepherd's Bush in London, Broadmeadows in Melbourne, Elizabeth in Adelaide, Balga in Perth, Ipswich in Brisbane, Sunderland in Tyne and Wear, Dapto in Wollongong and Charnwood in Canberra), or retail outlets frequented by Vicky Pollard.

In Australia, Lucas and Walliams were assisted by local comedians such as Gina Riley and Jane Turner (creators of Kath & Kim) for Melbourne references and Andrew Denton for Sydney.

A live Little Britain show was made for Comic Relief at the Hammersmith Apollo on 22 November 2006, and featured many guest artists and celebrities.