The musical premiered in regional theatre at the Guthrie, Minneapolis, Minnesota, followed by a tour in 2009-2010 of the United States, starting at the Paper Mill Playhouse in Millburn, New Jersey.

The cast included Melissa Gilbert as "Ma", Steve Blanchard as "Pa", Kara Lindsay (Laura), Jenn Gambatese (Mary), Sara Jean Ford (Nellie), Kevin Massey (Almanzo Wilder) and Brian Muller (Clarence Brewster).

The First National U.S. Touring Cast (2009–2010) included: Kara Lindsay as "Laura", Melissa Gilbert as "Ma", Steve Blanchard as "Pa", Kevin Massey as "Almanzo Wilder", Alessa Neeck as "Mary", Kate Loprest as "Nellie", and Carly Rose Sonenclar as "Carrie".

The cast also included (in alphabetical order) Taylor Bera, Michael Boxleitner, Megan Campanile, Kurt Engh, Shawn Hamilton, Jessica Hershberg, Meredith Inglesby, Caroline Innerbichler, Lizzie Klemperer, Garen McRoberts, Brian Muller, Will Ray, Tyler Rhodes, Gayle Samuels, Dustin Sullivan, Todd Thurston, Tony Vierling and Christian Whelan.

She finally sees that this is a good opportunity, and the family, including the young daughters Laura, Mary and Carrie, moves, settling in De Smet.