Little River is a 4.1-mile-long (6.6 km)[1] tributary of Casco Bay in Maine, United States.

The river's source is around 0.4 miles (0.64 km) west of Highland Road in Brunswick.

Just northeast of its mouth at Casco Bay, a 60-foot-long (18 m), single-track steel stringer bridge carries Burnett Road over the river.

[2] The shores of Little River are believed to have been seasonal fishing settlements historically.

[3] Its mouth is located between Wolfe's Neck Center for Agriculture & the Environment and Wolfe's Neck Woods State Park in Freeport.