The "Knowledge Quarter" is an area of Liverpool city centre covering 450 acres, incorporating the vicinity around London Road, Islington, the so called 'Fabric District', Paddington Village and part of Canning.

Since the mid-2000s, the Knowledge Quarter has been the subject of numerous Liverpool City Council masterplans and frameworks which have helped to cultivate the area's status as an innovation district based on science, technology, education, medicine and culture.

Early plans emerged in 2006 to incorporate Hope Street and Islington in to the Knowledge Quarter, Liverpool Vision (now defunct) followed with the publication of a prospectus to encourage collaboration between the district's various academic institutions in 2007.

The Liverpool Knowledge Quarter Strategic Investment Framework was formulated in 2011 to promote the area's branding and development.

In 2011/2012, Liverpool Vision continued to target the area for economic growth, job creation and attracting businesses in health and life sciences.

[9] In 2024, the UK central government pledged millions of pounds worth of investment to encourage more regeneration and life science laboratories at Paddington Village.

The school has made many contributions to tropical medicine, most notably the identification of the vector for malaria by Ronald Ross (who eventually went on the win a Nobel Prize for his discovery).

NOC began life as the Liverpool Observatory in 1843 and since then has continued to predict tidal activity and monitor overall sea conditions.

Its northern England headquarters is based at 'The Spine' building in Paddington Village, on the edge of Liverpool's Knowledge Quarter.

The RCP is a professional membership body for supporting physicians, raising standards in healthcare and promoting health in the UK and internationally.

The purpose-built building is clad in artwork in the form of 299 glass panels impregnated with a gold design in the theme of a printed circuit board.

[52] The building closed for refurbishment in December 2020 and as of 2024, has yet to re-open though in 2023 ownership was transferred to Sciontec, who also manage Liverpool Science Park.

[63][64] Mayor of the Liverpool City Region Steve Rotheram has promised to improve transport to Paddington Village and the wider Knowledge Quarter, which may in the future include some form of trackless tram technology.

In the 19th century, the combination of a large Jewish community and mass migration from Wales, Scotland, Ireland, Russia, Poland, Italy and Germany formed a distinctive and thriving district based on fabric, fashion and the rag trade, hence its modern day nomenclature.

However, Liverpool City Council, in partnership with the Fabric District CIC (set up in 2017), has committed to a long-term regeneration strategy.

The strategy will focus on physical improvements and sustaining an international, mixed-use creative community bolstered by a growing residential population.

It will also concentrate on light employment, makers, manufacturing, tech based businesses, more shops and services and re-integrating the area with surrounding districts.