[1] Born in Genoa, Giampalmo began her career on television in 1965 and in 1972, she made her acting debut in the film The Seduction of Mimi directed by Lina Wertmüller, yet she has mostly been active as a screenwriter and director.
[2] She most notably directed the 2004 film Stay with Me which starred her son Adriano Giannini.
She has dubbed Diane Keaton and Jane Fonda in a select few of their films as well as Goldie Hawn, Anne Bancroft, Kathleen Turner and Shelley Winters.
She notably dubbed Shelley Duvall in The Shining and Sigourney Weaver in Ghostbusters.
From 1967 until 1975, Giampalmo was married to actor Giancarlo Giannini.