She made her unofficial debut with 38 saves in a 2–1 exhibition win over NCAA Division I team Ohio State on September 30, 2006, and her official one two weeks later in a 5–2 victory against Windsor.

Knox and WLU picked right back up from there however, with the team plowing through CIS competition to the tune of a 25–3–2 regular season record and the goalie posting a 17–2–1 mark with a 0.945 save percentage and an 0.97 goals against average.

While the Golden Hawks won their first six post-season games (including sweeps of Queen's and Toronto en route to a fifth straight OUA title), the results were generally hard-earned.

[9] Following graduation, Knox was selected 18th overall in the 2011 CWHL Draft by the Brampton Thunder, part of a fruitful class for the team that also included Courtney Birchard, Tara Gray and Vicki Bendus.

In 2019, Knox ranked second among all CWHL players in an online vote, gaining the opportunity to serve as a captain at the 4th Canadian Women's Hockey League All-Star Game.

[20] During her final season at Laurier, Knox was selected to compete for Team Canada at the 2011 Winter Universiade in Erzurum, Turkey, along with two of her Golden Hawks teammates – defenceman Alicia Martin and forward Candice Styles.

[21][22] The 2011 tournament was just the second time that the biennial Universiade included women's ice hockey, and Knox helped Canada successfully defend its gold medal from 2009.

[25] The teams met once again in the gold medal match, although things were a bit less dramatic there, as Canada jumped out to a 3–0 lead early in the second period and cruised to a 4–1 win, helped in part by 20 Knox saves.

[26][27][28] Knox received a second call from Hockey Canada six months after the gold medal at the 2011 Winter Universiade and competed at the one-off 2011 IIHF 12 Nations Tournament, sharing the Canadian crease with fellow eventual CWHL netminders Geneviève Lacasse and Christina Kessler.

The stated goal of the 12 Nations Tournament was to enhance the competitive level of developing women's hockey countries ahead of the 2014 Winter Olympics and accordingly, no medals were awarded.

In that contest, Finland carried a 2–1 lead past the halfway point of the third period before goals by Meghan Agosta and Jennifer Wakefield, the latter with 2:00 remaining, flipped the result.