Her mother was a high school junior at the time of Miranda's birth, motivating her to drop out of education and begin to work to support her family.

[13] Citing President Trump's 2016 election as an important motivating factor,[13] Miranda launched a campaign to seek the fifth Suffolk seat in the Massachusetts House of Representatives after the incumbent, Evandro Carvalho, opted not to run for reelection, launching instead an unsuccessful bid for the Democratic party's nomination in the position of Suffolk County district attorney.

[16] In the general election, she faced Republican nominee Althea Garrison, a perennial candidate for the seat who had previously served as the district's representative from 1993 to 1995.

[19] On December 9, 2021, Rep. Liz Miranda announced her campaign for State Senate of the 2nd Suffolk District, which was redistricted in 2021, becoming the seat of political power for Boston's black community.

[citation needed] Winning 33% of the vote in fiercely contested Democratic primary, Liz Miranda defeated Nika Elugardo, Dianne Wilkerson, Miniard Culpepper, and James Grant on Tuesday, September 6, 2022.

[citation needed] She was endorsed by the Elect Black Women PAC, At-Large City Councilor Ruthzee Louijeune, District 7 City Councilor Tania Fernandes Anderson, Representative Liz Malia, the Boston Globe, Boston Carmens Union Local 589, the Environmental League of Massachusetts Action Fund, Boston's UNITE HERE Local 26, SEIU Local 509, Reproductive Equity NOW, National Association of Social Workers MA Chapter PACE, and the Massachusetts Nurses Association.

[citation needed] The new 2nd Suffolk District includes all of Roxbury with additional neighborhoods in Dorchester, Mattapan, Hyde Park, Mission Hill, Jamaica Plain, Roslindale, South End, and the Fenway.