[1] The series featured twelve contestants, from all over American Continent, competing for the title of La Más Draga of Mexico and Latin America and a cash prize of $500,000 MXN Pesos.

The winner of the fifth season of La Más Draga was Fifí Estah [es], with Hidden Mistake, Liza Zan Zuzzi and Paper Cut as runners-up.

The judges panel of this season include Mexican TV personality Maca Carriedo, who was also the main host, hair and makeup artist Yari Mejía, drag performer Bernardo "Letal" Vázquez, and Spanish actress and dancer Raquel Martínez.

The live auditions were broadcast on 15 and 16 March 2022, with three contestants confirmed to be cast by the judges and public vote (Deseos Fab, Fifí Estah and Liza Zan Zuzzi).

For this week's mini-challenge, the queens will participate in a trivia game called "No La Cagues" (Don't Shit the Bed).

For this week's mini-challenge, the queens will team up and improv in short sketches, developing a dramatic case, parodying court show Caso Cerrado.

Hidden Mistake, Huma Kyle, Isabella y Catalina, Light King and Paper Cut win the mini-challenge, and earn immunity from elimination this episode.

For the main challenge, the queens will present a black and white look that reveals into a full color look, inspired by Guillermo González Camarena.

Fifí Estah, Hidden Mistake and Light King win the mini-challenge, with all three of them earning 3 stars to their final challenge score.

For the main challenge, all eliminated contestants return for a chance to re-enter the competition; the queens will present a look inspired by a character from the works of Mexican filmmaker Guillermo del Toro.

For the main challenge the queens will record vocals and perform in ¡Chale, Lo hice otra vez!, a musical inspired by the songs of Britney Spears.

The Britney Spears songs inspirations, and their revised versions as well, were as follows: On the runway, category is La Más Tejocote (The Most Hawthorn).

Picking up from the events of the previous episode, the judges allow Light King to quit and then proceed to announce that the lip-sync between Aisha Dollkills and Peke Balderas will continue.

The next week, the queens participate in a mini-challenge called 'La Drag Ensebada' in which they must climb up a greased pole and grab a pair of pantyhose with the help of the past contestants they've been assigned.

For the main challenge, the queens must present a look inspired the Mexican Baroque tradition of Monja Coronada portraits, which must then reveal into a sexy Satan-inspired look.

Lastly, Gretha White and Hidden Mistake lip-sync to "Fulanito" by Becky G and El Alfa, however no one is declared the winner, leaving the both of them to sashay away.

All the queens, after walking the runway on the category Día de Muertas (Day of the Dead), return to talk about what happened this season.

Discussions include, Deseos Fab's tense elimination, her fight with Gretha White and feeling betrayed by Peke Balderas, Isabella y Catalina's rushed lip-sync against Liza Zan Zuzzi and feeling screwed over by the producers, Hume Kyle being the most viral queen, her messy track record and her drama with Santa Lucía, Light King's decision to quit and feeling unfairly critiqued by Raquel Martínez, Aisha Dollkill's dispute with Aviesc Who?, Peke Balderas' conflict with the Top 6 and the rumors about her supposedly spoiling the season, Hidden Mistake's preparation for the show and feeling that she was too harshly critiqued, Gretha White not posting anything about the show.

Liza Zan Zuzzi's romantic fling with Huma Kyle and apparently being favored by the producers, Paper Cut's harsh criticism he received upon his return and comparing his experience on both of his seasons, Fifí Estah's dance background and her not paying attention to all the hateful remarks from Aviesc Who?

It is then revealed that Fifí Estah is this season's La Más Volada (a prize sponsored by Viva Aerobus).

It is announced that Fifí Estah is the winner, leaving Hidden Mistake, Liza Zan Zuzzi and Paper Cut as the runners-up.