The band was founded in 1983 by brothers Lizzy Borden (born Gregory Charles Harges; June 23, 1960) and Joey Scott.

[2] The band is named after the notorious Lizzie Borden, a woman accused and acquitted of murder in the late 19th century.

The band issued their fourth studio album Master of Disguise, via their label Metal Blade, on July 15, 1989, and it has since become a cult classic.

The band was featured prominently in the rockumentary The Decline of Western Civilization Part II: The Metal Years (directed by Penelope Spheeris).

[6] In 1999, the band was once again fully active and touring with 3/5 of its classic lineup (Borden, Joey Scott & Alex Nelson) alongside longtime bassist Marten Andersson.

[7] In a 2008 interview with Lucem Fero, when asked about Alex Nelson, singer Lizzy Borden said: "He had a connection to everybody.

In November 2008, Lizzy Borden toured the United States with Finnish Monster Rockers Lordi.

Lizzy Borden was the first-day headliner of the two-day Keep It True XII festival at Tauberfrankenhalle in Lauda-Königshofen Germany 2009, where they introduced Gogo Dancers as part of their regular show routine.

On August 1, 2014, Lizzy Borden performed on Incheon Pentaport Rock Festival with former guitarist Ira Black.

[16] Lizzy Borden is currently working on a follow-up album,[17] and the band released its first song in five years, "Death of Me", on August 23, 2023.