Llano del Medio is an unincorporated community and census-designated place in Guadalupe County, New Mexico, United States.

Llano del Medio is one of several settlements located along the Pecos River in the Anton Chico Land Grant created by the government of New Mexico in 1822.

The early inhabitants were Hispanics and genizaros who migrated to LLano del Medio to attain land for growing crops and raising livestock.

Llano del Medio served as one of the eastern outposts of New Mexico to defend against Indian raids on settlements in the Rio Grande valley.

Many of the ciboleros (bison hunters) and comancheros (traders with the Plains Indians) of the 19th century came from the settlements along the Pecos River.