[7] From 1984 until 1988, he was a research fellow in vestibular neurophysiology at the University of Chicago Department of Pharmacological and Physiological Sciences, under the supervision of Jay M.

[7] In 1993 Minor joined the faculty of the Johns Hopkins University School of Medicine as an assistant professor[2] of laryngology and otology.

[7] In 2003 Minor was appointed the Andelot Professor and director (chair) of the Department of Otolaryngology–Head and Neck Surgery and otolaryngologist-in-chief at Johns Hopkins Hospital.

[1] On September 1, 2009[2] Minor became provost of Johns Hopkins University, making him both chief academic officer and the second-ranking member of the administration.

[12] At Stanford University, Minor also serves by courtesy as a professor of otolaryngology (head and neck surgery), bioengineering, and neurobiology.

[11] Minor has used his position as Dean to push for Stanford Medicine to focus on "precision health", which is intended to tailor care to patients' individual variations.

Minor espouses it as both a form of treatment and preventive medicine[14] that is focused on prediction by accounting for factors such as behavior and socioeconomic conditions.

[26] He published four key studies between 1999 and 2001 articulating the connection between head motion and eye movements and how they are controlled by the balancing mechanisms centered in the inner ear.

[4] Through neurophysiological investigations of eye movements and neuronal pathways, Minor has identified adaptive mechanisms responsible for compensation to vestibular injury in a model system for studies of motor learning (the vestibulo-ocular reflex).

By 2010, synergies between this basic research and clinical studies have led to improved methods for the diagnosis and treatment of balance disorders.

[4] In 1995 Minor discovered superior canal dehiscence syndrome, a debilitating disorder characterized by sound- or pressure-induced dizziness.