Part of the Erlanger-Elsmere School District, it has an enrollment of 515 students in grades 9–12.

[2] Its boundary includes portions of Erlanger, Edgewood, and Elsmere.

The school was named after the pharmacist John Uri Lloyd, who gave money and books for the new school.

[4] In 1956, the school was one of the first high schools in the United States to be racially desegregated after the United States Supreme Court's decision in Brown v. Board of Education.

Its success in doing so was featured in a Life magazine article.