Llyswen Historic District is a national historic district located at Altoona in Blair County, Pennsylvania, United States.

The district includes 166 contributing buildings in a residential area of Altoona.

The buildings are primarily single-family dwellings built between 1895 and 1940, and reflect a number of popular architectural styles including Colonial Revival and Queen Anne.

Notable non-residential buildings include the Llyswen Methodist Episcopal Church, Ward Avenue United Presbyterian Church, Baker Elementary School and Llyswen Station.

[2] The district was added to the National Register of Historic Places in 2002.