The first written mention of Loštice is from 1267, in a deed of bishop Bruno von Schauenburg.

In 1414, Loštice was acquired by Boček II of Poděbrady as a part of the Bouzov estate.

The D35 motorway (part of the European route E442), which connects Olomouc with the Hradec Králové Region, runs east of the town.

Among the most significant monuments belongs the former synagogue, today a library and a small museum, and the Church of Saint Procopius.

The church with the late Gothic core was rebuilt to its current Neoclassical form at the end of the 18th century.