The song features Dominican-American singer Leslie Grace and producers Play-N-Skillz; it was released on Replay (2018), a repackaged version of the band's eighth studio album Play (2017).

Daniel "Obi" Klein, Charli Taft, Andreas Oberg, and Juan "Play" and Oscar "Skillz" Salinas composed the song, and its lyrics were written in Korean, Spanish and English by Kenzie, Mario Caceres, Yasmil Marrufo, Grace, as well as Super Junior members Heechul and Eunhyuk.

The song describes love at first sight; it marks the band's first collaboration with foreign artists and their first venture into Latin pop.

[3][2] The album's title track was described as a unique concept that is "180 degrees opposite" to the band's usual musical style.

[3] A teaser image was released on March 27, 2018, and it was announced new tracks "Lo Siento", "Me & U", "Super Duper" and "Hug" would be included on the repackaged album.

[4] The single included only seven of the eleven members of Super Junior;Leeteuk, Heechul, Yesung, Shindong, Eunhyuk, Siwon and Donghae.

[5] Other band members did not participate for various reasons; Kyuhyun and Ryeowook were carrying out their mandatory military service while Kangin and Sungmin were on hiatus.

[5] Although Heechul appeared in the teaser image, Label SJ announced he would not participate in the album's promotion because of health issues.

[6] The single is the band's first collaboration with foreign artists; it was produced by Play-N-Skillz and features Dominican-American singer Leslie Grace.

[10]In another interview, Grace praised Super Junior's approach to the collaboration, saying the band were "open to learning about [Latin] culture, and why we use certain sounds".

[24] Billboard's Tamar Herman stated "Lo Siento" stands out from other Latin-pop songs in the K-pop scene because it is a "full-fledged international production that was crafted by different songwriters".

[19] Yoon Gi-baek from Sports World stated the song stands out because it "maintains the Latin vibe, yet it did not lose the identity of Super Junior".

[26] Electronic Times writer Park Dong-seon said along with other K-pop songs released in early 2018, "Lo Siento" "reveal[s] sophisticated refreshing looks with light yet elegant choreography and delicate emotional line of vocals".

[53] They also promoted the song on Mexican talk show Montse y Joe, in which they performed a mariachi version of "Lo Siento".