Local Route 22 Yeosu–Suncheon Line (Korean: 국가지원지방도 제22호선 여수 ~ 순천선) is a local route of South Korea that connecting Sepo 3-IS in Hwayang-myeon, Yeosu, South Jeolla Province to Sungo 5-IS in Jangcheon-dong, Suncheon, South Jeolla Province.

This route was established on 19 July 1996.

IS: Intersection, IC: Interchange Deogyang IS – Sangbi IS segment is a motorway, so only car can be driven.