[1] Before the end of the reign of King Henry III (1216–1272), the Hospital and Brethren acquired a great deal of land in both Spondon and the surrounding hamlets of Borrowash, Chaddesden and Locko.

[2] The Taxatio Ecclesiastica of 1291–92 gave the preceptory an annual "real income" of around £77 7s., around a third of which would have been expected to have been given in tribute to the Order's mother-house and Grand Master who, at this time, resided in France.

Following the capture of Robert de Ferrers, 6th Earl of Derby in 1266, following his rebellion against King Henry III, de Ferrers' lands and estates were confiscated; the associated from 1266 documents reveal there was a preceptory and leper hospital of the Order of St Lazarus at Locko, dedicated to St Mary Magdalene.

[2] One such of the English Brethren was "Hugh Michel" who was Master at Burton Lazars; his colleagues however remained loyal to the mother-house and so Michel retired to Locko Preceptory where he was granted a house for life in return for the priory paying £20 a year to the mother-house in France.

was to pay £20 a year (the sum they had previously paid in tribute to their mother-house in France) to the "warden and scholars" at the newly founded King's Hall, Cambridge.

[2] Michel's aim for independence from French control did partially come true, as his successor, Thomas de Kirkeby, has to ask permission of King Edward III to travel to inspect the Order's English properties; this permission was usually granted by the French mother-house, suggesting authority had passed to the English King.

[2] At the end of the Hundred Years' War the Lazarite property was probably transferred to the brethren at Burton Lazars; the chief leper house of the order in England.